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In July 2004, the National Pharmaceuticals Agency of England (NPMA) granted an application for the marketing authorisation of sildenafil (Viagra) under the Medicines and Healthcare products Regulatory Agency (MHRA). This application was made under the supervision of the Committee for Medicinal Products on Medicinal Products and Devices (CMMPPD) (formerly the MHRA). The applicant, Pfizer, UK, has a patent for sildenafil citrate (the generic name for Viagra) which is the subject of a patent application for a license for the drug in Europe. The applicant, Pfizer is entitled to a licence for sildenafil citrate for a number of years. The patent is held by Pfizer and it has expired in Europe. The application for the license is based on the findings of the patent application and is therefore subject to a patent infringement litigation.

The applicant has submitted applications for a license for sildenafil citrate to be granted under the guidance of a specialist in pharmaceutical products and devices, including a pharmacist. The application is to be submitted in the spring of 2005.

The applicant is a specialist in the field of viagra, a treatment for erectile dysfunction (ED). The applicant has received applications for a licence to market sildenafil citrate to patients in the European Union (EU). The applicant is a pharmacist with expertise in the subject of sildenafil citrate. The applicant has received applications for a licence to sell sildenafil citrate for patients to patients. The applicant has a license to sell sildenafil citrate for the treatment of ED in Europe.

The applicant has applied for a license to sell sildenafil citrate for the treatment of ED in the EU. The applicant is a specialist in the field of sildenafil citrate and a pharmacist with expertise in the subject of sildenafil citrate. The applicant has received applications for a licence to sell sildenafil citrate for the treatment of ED in the EU.

The applicant is a specialist in the field of sildenafil citrate.

The applicant has applied for a licence to sell sildenafil citrate for the treatment of ED in the EU.

The applicant has received applications for a license to sell sildenafil citrate for the treatment of ED in the EU.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
‍ dynamics of combining tadalafil and alcohol ‍
Tablet- and Cialis-Related Interactions

The aim of this study is to (1) explore whether tadalafil can and may be used as a post-oral dosage in patients with erectile dysfunction, (2) explore whether tadalafil can be used as a post-oral dosage in patients with erectile dysfunction who also have erectile dysfunction, and (3) explore whether tadalafil is safe and effective in treating erectile dysfunction.

Tadalafil and Alcohol

Both tadalafil and alcohol can cause QT prolongation, (4) increase blood pressure, and (5) interact with certain foods and beverages. By explore these interactions, healthcare providers can (1) monitor for potential side effects (2) increase alcohol consumption while on tadalafil and (3) enhance the effectiveness of tadalafil for patients with erectile dysfunction.

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The cheapest erectile dysfunction (ED) pills are generic Viagra, called.

What is a generic drug?

The term "generic" refers to the active ingredient of a medicine or drug rather than to the advertised brand name under which the medicine is sold. It is a term referring to any drug marketed under its chemical name without advertising.

Pfizer made the originaltablet that is often referred to as the “blue pill”.The patent expired in 2013 which then allowed other pharmaceutical manufactures to make a generic version under the name of the active ingredient called Sildenafil. They are exactly the same medically and perform in the same way with the same side-effects.

As with most branded products, Viagra is sold at a higher price,therefore the generic tablets sold asare much cheaper.

What is the difference between generic and branded drugs?

Medically there is no difference between a generic medicine and the branded medicine, as they both have the same active ingredients to make them perform in the same way. They only differ in the “bulking” agents used to fill the tablet as the amount of active ingredient required, in this case Sildenafil, is very small. This makes the tablets bigger and easier to handle.

The main difference between generic andbranded named prescription medicines is cost with generics being much cheaper

Every pharmacy can choose what price they sell at, as there are no fixed prices. It will depend on what price the pharmacy can buy the drug from the wholesaler and the cost of their own overheads. They can they decide what mark-up they require and some pharmacies choose to sell some products at higher prices.

At Webmed pharmacy we aim to keep our prices as low as possible, without compromising the quality of service, as we arethe only online pharmacy to offercourier guaranteed next working day as standard

We offer a very fast, confidential and discreet service that isby the General Pharmaceutical Council (GPhC) and the Care Quality Commission (CQC).

A large proportion of our sales are made up of returning customers as they have been delighted with our service.

What is the best brand of sildenafil?

When you choose to buy any prescription medication online, you must first of check that the pharmacy is with the General Pharmaceutical Council (GPhC).

All pharmacies using a UK General Medical Council, to prescribe their medicines will also be registered with the UK government Agency the Care Quality Commission (CQC).

Those online pharmacies who are not registered with the CQC either use pharmacist prescribers or foreign doctors.

You will then know and have the confidence that all the brands being offered are genuine and will work in the same way. All the pharmaceutical companies are inspected by the Medicines and Healthcare products Regulatory Agency (MHRA) to ensure they manufacturer the drugs to the same quality standard. This means that the key ingredient that is referred to as the “active” ingredient is exactly the same in all brands.

The other inactive ingredients that make up the bulk of the tablet are called “excipients” and can vary.

For those people who are allergic to or have an intolerance to lactose, then the is ideal for you as it is lactose free. You can check the additional excipients on the patient information leaflet supplied with your tablets.

Although medically all the generic tablets are identical, they may look different as they can vary in colour, shape and size due to the varying excipients.

The patent for, owned by Pfizer, expired in July 2013, which then allowed other pharmaceutical companies to produce generic. There are a number of companies now manufacturing which include Accord, Ajanta, Dr Reddy’s, Mylan, Teva, Torrent and Zentiva. Even Pfizer make a that they sell cheaper than Viagra although generally more expensive than the equivalent generic brands.

Author 19th September 2019

Active ingredient Sildenafil struck an agreement with Webmed on 28 February 2019 for a (in addition to Teva and silos).</Active Ingredient used: Sildenafil2mg The main excipients are then you can also find on the patient information leaflet.

Product Details

Type Of MedicinesViagra, Cialis
Dosage25mg
FormTablet
UsageFor the treatment of erectile dysfunction
FormsCup of Viagra, Cialis
BrandViagra
ManufacturerCenturion Laboratories Pvt. Ltd.
ApplicationErectile Dysfunction
Country of OriginMade in India

The original brand of Viagra is Sildenafil. It is a phosphodiesterase type 5 (PDE5) inhibitor and is used to treat erectile dysfunction (impotence) in men. The medication works by helping to relax the blood vessels in your penis. It will not help you if you do not have erectile dysfunction. The medication will not work if you do not have erectile dysfunction. This medicine is available only with your doctor's prescription.

Cialis

The original brand of Cialis is Tadalafil. Cialis is not available in the form of tablets or oral pills. It is only available with a doctor's prescription.

Levitra

The original brand of Levitra is Vardenafil. Levitra is not available in the form of tablets or oral pills.

Stendra

The original brand of Stendra is Vardenafil. Stendra is not available in the form of tablets or oral pills.

Tadalafil

The original brand of Tadalafil is Tadalafil. Tadalafil is not available in the form of tablets or oral pills.

Spedra

The original brand of Spedra is Vardenafil.